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Your Routine Can't Fix What's Missing on the Inside
There's a reason your expensive beauty products aren't delivering the results they promised. Topical products only work on the surface — but your skin, hair, and nails are built from the inside, by your cells. And your cells need one raw material most people aren't getting enough of: sulfur.
Sulfur is what your body uses to produce collagen (for firm, hydrated skin) and keratin (for strong hair and nails). It also fuels glutathione — your body's most powerful antioxidant — protecting against the UV, pollution, and oxidative stress that age you from the outside in.
MSM is the most bioavailable form of organic sulfur you can find — delivering what your cells need in a form your body can actually use. Across multiple double-blind, placebo-controlled clinical studies, daily MSM supplementation has been shown to reduce wrinkles, improve skin firmness and elasticity, increase hair shine and volume, and strengthen nails — with visible changes in as little as 6-8 weeks.
This isn't another beauty trend. It's the cellular support your routine has been missing.
Your Skin is Only as Healthy as Your Cells
Every serum, cream, and mask you own works on the surface. But your skin is built from the inside — by your cells. When those cells don't get enough sulfur, they can't produce the collagen and keratin that keep skin firm, hair strong, and nails tough.
MSM delivers bioavailable sulfur directly to your cells — the same sulfur your body uses to build collagen and keratin. It's why sulfur has been called "Nature's Beauty Mineral." And unlike collagen supplements that break down during digestion, MSM gives your body the raw material to produce its own collagen naturally.
In a clinical study, MSM was shown to affect the expression of 92 genes involved in skin health and function.
Real beauty starts at the cellular level. If your cells don't have what they need, no topical product can make up the difference.
Fewer Wrinkles. Firmer Skin. More Glow.
Collagen is the protein responsible for keeping your skin firm, hydrated, and youthful. As you age, your body produces less and less of it — and that's when fine lines, sagging, and dullness start to show. MSM helps your body ramp its own collagen production back up.
Across multiple randomized, placebo-controlled clinical trials, daily MSM supplementation consistently outperformed placebo for key markers of skin aging — including how skin looks, feels, and holds moisture.
Wrinkle improvements visible as early as 8 weeks
Skin hydration improved up to 17.6%
Skin elasticity improved up to 22.6%
Significant improvements in skin firmness, tone, and texture at 16 weeks
Supporting your own collagen production means fewer fine lines, more bounce, and a glow you can't get from a bottle alone.
Calmer Skin. Less Redness. Fewer Breakouts.
Chronic inflammation is behind more skin problems than most people realize — from persistent redness and rosacea flare-ups to acne breakouts that never fully clear. When inflammation stays elevated, it damages skin cells, disrupts healing, and keeps your complexion stuck in a cycle of irritation.
MSM is a natural anti-inflammatory. It works by lowering the pro-inflammatory signals (like TNF-α and IL-6) that drive redness and swelling, while simultaneously supporting the collagen production and cell turnover your skin needs to heal and recover. Research has shown that MSM helps reduce redness and irritation in people with rosacea — and its collagen-boosting properties may help fade acne scars over time.
Stronger Hair. Healthier Nails. Less Breakage.
Keratin is the protein that gives your hair its strength and your nails their toughness. Sulfur bonds are what hold keratin together — and without enough sulfur, those structures weaken. The result? Thinning hair, breakage, and nails that split just from daily life.
MSM provides the raw sulfur your body needs to build stronger, healthier keratin. And in clinical research, the results were striking — verified not just by participants, but by independent expert grading.
Nearly 30% improvement in hair shine by week 16
Significant increase in hair volume after 8 weeks
93% of participants with stress-related hair loss reported new hair growth after 45 days
Significant improvement in nail condition over 4 months
If you're spending money on hair and nail supplements, ask yourself: are they giving your body the building blocks it actually needs? MSM does.
Built-In UV and Pollution Defense for Your Skin
Every day, your skin takes hits from UV rays, pollution, and environmental toxins. These create free radicals — unstable molecules that damage your cells and accelerate visible aging. Your body's best defense? Glutathione — often called the "master antioxidant."
MSM fuels your body's production of glutathione, giving your skin a powerful internal defense system against the environmental stressors that cause premature aging, dullness, and uneven skin tone. One clinical trial found significant improvements in skin smoothness in as little as 6 weeks, with continued reductions in wrinkle depth through week 12.
Sunscreen protects the outside. MSM helps protect from the inside. Together, they're a smarter defense against premature aging.
Beauty Is Just the Beginning
When your cells are nourished, protected, and functioning at their best, the benefits go way beyond skin deep. MSM improves the permeability of your cell membranes — making it easier for nutrients to get in and toxins to get out. It's like upgrading the delivery system for every cell in your body.
That's why our customers don't just report beauty benefits. They notice reduced joint pain, faster workout recovery, more energy, stronger immunity, and less inflammation throughout their body. It's the difference between treating symptoms and fixing the root cause.
Sulfur is the 3rd most abundant mineral in your body, involved in over 150 vital functions — and most people aren't getting enough.
Healthier cells don't just look better. They perform better — in everything from recovery to immunity to daily energy. That's not beauty hype. That's biology.
Are You Getting Enough Sulfur?
A century ago, sulfur-rich organic matter in healthy soil meant that vegetables, grains, and proteins naturally contained high amounts of this essential mineral.
Today, industrial farming, synthetic fertilizers, and heavy food processing have stripped sulfur from the soil — and from the food supply. Most people are now chronically low in a mineral their body uses for over 150 vital functions, from detoxification and joint health to immune defense and skin repair.
Just look at how much food it would take to match a single scoop of MSM Cellular Detox. Getting enough sulfur from food alone is practically impossible in the modern diet.
50 garlic cloves. 16 eggs. 6 lbs of onions. 1 scoop of MSM does it all.
Hear Real Human Improvement
4.9/5 Stars
“I love this stuff sooo much"
I just got my second bag so I've been on it for a month and it's AMAZING. My hair has grown insanely fast, lines & wrinkles disappearing AND I FEEL AMAZING. The joy and energy is insane.
Christal C.
“Truly a life changer"
This MSM changed my life! I have been taking it for almost 3 years now. I take it first thing in the morning and it helps me detox within the hour. My skin has cleared up, my nails are stronger and my overall inflammation has gone down from being super active. Love this product. Key is consistency!
Gina R.
“Everyone needs this!”
I recently had a root canal and the recovery and healing has been much quicker than even my dentist expected! My mind seems more clear, I'm sleeping better, I'm recovering from workouts easier and I'm less anxious as well. My hair and nails are growing like crazy too!!
Heather K.
Why Human Improvement?
99.9% Pure MSM
Quadruple
(4x)Distilled
Made in the USA
3rd Party Tested
Money Back Guarantee
MSM
Cellular Detox
Generic MSM
Improve your cells. Improve your life. Human Improvement.
We searched the world to bring you the cleanest, most effective MSM - so you can get the sulfur you need.
🇺🇸 Made in the USA
🔬 3rd Party Tested
🌿 4x distilled, 99.9% pure
🤝 60 day, money-back guarantee
🤑 From just $0.45 per serving
Get 15% OFF your first order with code MSM15
Start glowing from the inside out.
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FAQs
What is the 100% money-back guarantee?
Try Human Improvement risk free! If you don't love it, we will issue you a full refund within 60 days of your first order. Due to shipping constraints, this is only valid for orders in the continental US under $90.
What studies back up the claims?
You can check them all out below!
[1] Muizzuddin N, Benjamin R. Benefits of a skin care regimen containing methylsulfonylmethane (MSM) and silymarin on skin blemishes and skin elasticity in aging skin. J Aging Res Clin Practice. 2013;2(4):374–377. [Skin elasticity, hydration, wrinkle reduction — 16-week RCT]
[2] Anthonavage M, Benjamin R, Withee E. Effects of oral supplementation with methylsulfonylmethane on skin health and wrinkle reduction. Natural Medicine Journal. 2015;7(11). [12-week double-blind, placebo-controlled trial — skin smoothness, wrinkle depth, antioxidant activity]
[3] Nole G, et al. Efficacy and safety of methylsulfonylmethane on hair and nail quality. [Double-blind, placebo-controlled study, 63 participants, 16 weeks — 12–30% improvement in hair shine; significant nail quality improvements confirmed by expert clinical grading]
[4] Aguirre A, et al. Randomized, double-blind clinical trial evaluating MSM combined with hydrolyzed fish collagen on skin elasticity. Journal of Cosmetic Dermatology. [MSM + hydrolyzed fish collagen produced superior skin elasticity improvements vs. either ingredient alone]
When will I start to feel the difference?
Most people notice the non-beauty benefits first — things like more energy, less inflammation, less aches and pains, and better recovery tend to show up within the first 2-4 weeks of daily use.
The beauty benefits take a little longer because your body needs time to build up its sulfur stores and ramp collagen and keratin production back up. Here's what the clinical research shows:
Weeks 2-4: MSM reaches peak levels in your system. Some people notice early improvements in skin hydration and a general "glow" during this window.
Weeks 6-8: Clinical studies show measurable improvements in skin smoothness, wrinkle reduction, and skin firmness starting around this timeframe. Hair shine improvements have been documented as early as 4 weeks.
Weeks 8-12: This is where it starts to compound. Skin elasticity, tone, and firmness continue improving. Hair shine improvements become more pronounced — up to 22.9% improvement over baseline in clinical studies.
Months 3-4: The most significant results for hair volume, nail strength, and overall skin appearance. One study showed nearly 30% improvement in hair shine by week 16.
How is MSM different from collagen supplements?
They're actually solving the same problem from different angles — but MSM has a key advantage.
Collagen supplements try to deliver collagen directly into your body. The problem is that collagen is a large protein molecule, and your digestive system breaks it down into basic amino acids before it can be absorbed. By the time it reaches your skin, it's no longer collagen. Your body then has to reassemble those amino acids into new collagen — and there's no guarantee it gets directed to your skin, hair, or nails.
MSM works upstream. Instead of delivering a finished product that gets broken down, MSM gives your body bioavailable sulfur — one of the key raw materials it needs to produce its own collagen naturally. Sulfur forms the disulfide bonds that give collagen its structure and strength. Without enough sulfur, your body can't build or maintain quality collagen no matter how much collagen powder you take.
Think of it this way: collagen supplements hand your body a finished product that may or may not get used. MSM gives your body the building materials and lets it do what it does best.
That said, they're not competitors — one clinical study actually found that combining MSM with collagen produced better improvements in skin elasticity than either one alone. But if you're choosing one place to start, MSM gives you the foundation. It supports collagen production, keratin production, AND glutathione (your body's master antioxidant) — which means you're getting skin, hair, nail, and antioxidant benefits from a single supplement.
What does it taste like?
The taste is fairly bitter but it washes it right away with water, juice, coffee, or whatever beverage you want. To make the cellular detox as pure and effective as possible, we did not use any additional flavoring or ingredients.
It takes a little bit of time to get used to it but lots of people end up craving it after taking for a few weeks!
What is silicon dioxide? Is it safe?
There is a ton of misinformation out there on silicon dioxide which can make things confusing! Silicon dioxide is a natural compound found in many foods and even naturally inside the body.
There are two types, amorphous, which is what is generally found in food products and crystalline which is found in materials like quartz and sand.
Amorphous silicon dioxide, which is what we use, is well studied and classified as safe in foods. When ingested, amorphous silica is poorly absorbed by the gut and is typically excreted without significant metabolism or accumulation in the body. In fact, it is used in many binders to help with the detox.
Crystalline silicon dioxide, on the other hand, is what can pose some health risks but that is when it is inhaled. Furthermore, that concern primarily applies to industrial or occupational exposure (e.g. grind mortar, saw, drill concrete, or manufacture brick, concrete, stone, or ceramic) by breathing in dust, not oral ingestion.
So when people start talking about the dangers of silicon dioxide, they are most often mixing up the two and talk about the health risks of inhaling crystalline silicon dioxide, not ingesting amorphous silicon dioxide.
Silicon dioxide makes up less than 0.5% of a serving in the MSM Cellar Detox and it makes it significantly smoother and helps it dissolve in water. Without that, it is very crystalline and is difficult to dissolve which a lot of customers complained about plus it tastes way worse!
Can I take this if I have a sulfa allergy?
Yes you can! MSM does not contain sulfonamides, so it is generally safe for those with sulfa allergies. MSM is an organic sulfur compound, but it is not a sulfonamide. There is no known cross-reactivity between sulfonamide drugs and MSM. That being said, it is always good to start with a low dose and work up from there!
Can I take if I have a MTHFR gene variant?
Many people with MTHFR variants take MSM without issue. However, because of potential differences in sulfur metabolism and detoxification, we always suggest people with MTHFR variants start with smaller doses and work their way up!
MSM contains sulfur which is involved in detoxification pathways in the liver. Because of this, some people with MTHFR (or other genetic variations) who have impaired detoxification or sulfur-processing pathways may find sulfur-containing supplements beneficial—or, in some cases, they may be more sensitive to them.
While MSM does contain a “methyl” component in its name (methylsulfonylmethane), its primary function in the body is not tied to the same folate- and B-vitamin–dependent methylation pathways as 5-MTHF or methylcobalamin (methylated B12).
Do I need to take a binder with this?
No you don't! MSM supports detoxification by enhancing cellular function and promoting the body’s natural elimination pathways—like liver, kidneys, and lymph—not by forcefully mobilizing large amounts of toxins like some aggressive detoxes. That said, if someone is doing a more intense or targeted detox protocol, adding a binder could be helpful. But for daily cellular support and detox, most people do well with MSM on its own.
Can MSM help with long COVID symptoms?
While there’s no official cure for long COVID, MSM may help support your recovery—especially if you’re dealing with fatigue, brain fog, muscle aches, or inflammation.
MSM is known for its powerful anti-inflammatory and antioxidant effects. It helps reduce oxidative stress, supports your body’s natural detox pathways, and promotes a more balanced immune response—all of which can be disrupted in long COVID.
It’s not a magic bullet, but for many people, MSM can be a valuable part of feeling like themselves again. You can learn more about it here.
Are there side effects of the detox?
The vast majority of people tolerate MSM extremely well—with no side effects at all. But because MSM supports your body’s natural detox pathways, a small subset of users may experience some mild, temporary discomfort when they first start taking it.
This can include things like slight fatigue, mild headaches, or digestive changes—all signs that your body is beginning to release and process stored toxins. These effects typically fade quickly as your system adjusts. Staying hydrated and consistent with your daily dose can help ease the transition.
How long should I take the MSM Cellular Detox?
You can take as long as it continues to make you feel good! Some people take it for a few months to clean out their cells and reduce systemic inflammation but most people continue to take it because it makes them feel so good!
Does MSM have any prescription medication interactions?
MSM is generally well-tolerated and has a very low risk of interacting with prescription medications. It’s not known to interfere with most drug pathways, and there are no widely documented interactions with common medications.
That said, because everyone’s health and medication profile is unique, we always recommend checking with your healthcare provider before starting MSM — especially if you’re taking blood thinners, diabetes medications, or undergoing treatment for a specific condition.
When in doubt, it’s best to start with a lower dose and see how your body responds.
What is the best way to take it?
Start with ½ tsp (½ scoop) twice a day and work up to 1 tsp (1 scoop) twice a day or as directed by your healthcare provider.
Put the MSM directly on your tongue and swallow with water or dissolve directly into 2oz of water. For the best experience, use hot water when dissolving. Many people also like to use coffee or juice since they have a stronger flavor to wash out the taste of the MSM.
How are MSM and organic sulfur related?
MSM contains approximately 34% organic sulfur by weight, making it one of the most efficient ways to deliver this essential mineral to your cells.
Sulfur is the 3rd most abundant mineral in your body and involved in over 150 vital bodily functions. Unfortunately, due to current farming practices and our food systems, many people are currently deficient.
You can read all about organic sulfur and why it is important here.